BP501T: Medicinal Chemistry – II
Sorted Question Bank (2020-2025)
Table of Contents:
UNIT – I: Antihistaminics, PPIs, and Anti-neoplastic Agents
10 Marks (Essays)
- Define and classify anti-histaminic agents with examples. Write the synthesis and mechanism of action of any one H1 antagonist. (Nov 2024)
- Classify anti-neoplastic agents with examples. Explain the chemistry, mechanism of action and synthesis of any one antimetabolite. (July 2024)
- Define and classify alkylating agents. Describe the mechanism of action and synthesis of any one alkylating agent. (Jan 2020)
- Enumerate the classification of alkylating agents with examples, mechanism of action and synthesis of meclorethamine. (Jan 2021)
5 Marks (Short Notes)
- Describe about histamine receptors and their distribution in the human body. (May 2023, Nov 2024, Jan 2021)
- Chemistry, synthesis, and uses of cimetidine. (July 2024, Dec 2023)
- Chemistry and synthesis of meclorethamine. (Nov 2024)
- Plant products used as anti-neoplastic agents. (Nov 2024)
2 Marks (Brief Answers)
- Structure of omeprazole and chlorambucil. (Sept 2023)
- Structure and uses of methotrexate. (May 2023, Jan 2020, May 2025)
- Why loratadine is less sedative than first-generation H1 antihistamines? (May 2025)
UNIT – II: Anti-anginals, Diuretics, and Anti-hypertensives
10 Marks (Essays)
- Define and classify diuretics with examples. Write the synthesis and mechanism of action of any one thiazide diuretic. (May 2023, May 2025)
- Classify anti-anginal drugs with examples. Explain the chemistry, mechanism of action and synthesis of any one vasodilator. (May 2023)
- What are antihypertensive agents? Classify them with examples and write the synthesis of furosemide and acetazolamide. (Jan 2020, Jan 2021)
5 Marks (Short Notes)
- Structure, mechanism of action and uses of nitroglycerin and isosorbide dinitrite. (Sept 2023)
- Classify anti-hypertensive agents and write the structure/uses of captopril. (Sept 2023, May 2023)
- Mechanism of action and synthesis of nitrovasodilators. (Jan 2020, Nov 2021, May 2025)
UNIT – III: Anti-arrhythmics, Anti-hyperlipidemics, Coagulants, and CHF
10 Marks (Essays)
- Explain the classification, chemistry, and mechanism of action of antiarrhythmic agents and write the synthesis of Disopyramide. (Dec 2023)
- Classify anti-hyperlipidemic agents with structures and explain the mechanism of action of any two. (Nov 2021, July 2022)
5 Marks (Short Notes)
- Drugs used in congestive heart failure (CHF) and cardiac glycosides. (May 2023, July 2024, Sept 2023)
- Chemistry and synthesis of disopyramide phosphate. (Sept 2023, May 2025, Jan 2021)
UNIT – IV: Endocrine System (Steroids, Hormones, and ED Drugs)
10 Marks (Essays)
- Explain briefly on the nomenclature, stereochemistry, and metabolism of steroidal hormones. (Jan 2023)
5 Marks (Short Notes)
- Structure, mechanism of action and uses of L-Thyroxine and Methimazole. (July 2024, Jan 2020)
- Mechanism of action and uses of sildenafil and cortisone. (Nov 2024)
- Outline the metabolism of steroids. (Nov 2024, July 2022)
UNIT – V: Antidiabetics and Local Anesthetics
10 Marks (Essays)
- Classify anti-diabetic agents with examples. Explain chemistry, MOA, and synthesis of any one sulfonylurea. (Sept 2023)
- Define and classify local anaesthetics with examples. Write the synthesis and MOA of any amino benzoic acid derivative. (Sept 2023, Jan 2023)
5 Marks (Short Notes)
- Short note on insulin and its various preparations. (Sept 2023, Dec 2023, July 2022)
- SAR of local anaesthetics. (July 2024, Jan 2020, Dec 2023)
- Synthesis and uses of benzocaine and procaine. (Jan 2021, July 2022)
*Compiled for study purposes from previous year pharmacy degree examinations.
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